{"id":2332,"date":"2016-06-19T14:55:58","date_gmt":"2016-06-19T12:55:58","guid":{"rendered":"https:\/\/jakobssonlab.iob.uu.se\/?p=2332"},"modified":"2024-11-19T15:07:04","modified_gmt":"2024-11-19T14:07:04","slug":"new-approach-to-tracking-population-changes","status":"publish","type":"post","link":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/2016\/06\/19\/new-approach-to-tracking-population-changes\/","title":{"rendered":"New approach to tracking population changes"},"content":{"rendered":"\n<p>A new <a href=\"http:\/\/www.genetics.org\/content\/early\/2016\/09\/15\/genetics.115.185058\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #990100;\">publication<\/span><\/a> by Lucie Gattepaille, Torsten G\u00fcnther and Mattias Jakobsson describes a new approach to investigate population size changes in the past.<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1534\/genetics.115.185058\" target=\"_blank\" rel=\"noreferrer noopener\">Gattepaille et al. 2016. Inferring Past Effective Population Size from Distributions of Coalescent Times. Genetics, Volume 204, Issue 3. https:\/\/doi.org\/10.1534\/genetics.115.185058<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\" style=\"margin-top:var(--wp--preset--spacing--70);margin-bottom:var(--wp--preset--spacing--70)\"><img decoding=\"async\" src=\"https:\/\/jakobssonlab.iob.uu.se\/wp-content\/uploads\/2024\/11\/Genetics-2016-m_cover.gif\" alt=\"\" class=\"wp-image-2333\" style=\"width:300px\"\/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"379188982\">Abstract<\/h2>\n\n\n\n<p>Inferring and understanding changes in effective population size over time is a major challenge for population genetics. Here we investigate some theoretical properties of random-mating populations with varying size over time. In particular, we present an exact solution to compute the population size as a function of time,&nbsp;Ne(t)\u2060, based on distributions of coalescent times of samples of any size. This result reduces the problem of population size inference to a problem of estimating coalescent time distributions. To illustrate the analytic results, we design a heuristic method using a tree-inference algorithm and investigate simulated and empirical population-genetic data. We investigate the effects of a range of conditions associated with empirical data, for instance number of loci, sample size, mutation rate, and cryptic recombination. We show that our approach performs well with genomic data (\u2265 10,000 loci) and that increasing the sample size from 2 to 10 greatly improves the inference of&nbsp;Ne(t)&nbsp;whereas further increase in sample size results in modest improvements, even under a scenario of exponential growth. We also investigate the impact of recombination and characterize the potential biases in inference of&nbsp;Ne(t)\u2060. The approach can handle large sample sizes and the computations are fast. We apply our method to human genomes from four populations and reconstruct population size profiles that are coherent with previous finds, including the Out-of-Africa bottleneck. Additionally, we uncover a potential difference in population size between African and non-African populations as early as 400 KYA. In summary, we provide an analytic relationship between distributions of coalescent times and&nbsp;Ne(t)\u2060, which can be incorporated into powerful approaches for inferring past population sizes from population-genomic data.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new publication by Lucie Gattepaille, Torsten G\u00fcnther and Mattias Jakobsson describes a new approach to investigate population size changes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2333,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,18,11],"tags":[58,36,57],"class_list":["post-2332","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-publications","category-research","tag-coalescent-time","tag-human-past","tag-population-size"],"_links":{"self":[{"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/posts\/2332","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/comments?post=2332"}],"version-history":[{"count":1,"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/posts\/2332\/revisions"}],"predecessor-version":[{"id":2334,"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/posts\/2332\/revisions\/2334"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/media\/2333"}],"wp:attachment":[{"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/media?parent=2332"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/categories?post=2332"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/tags?post=2332"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}