{"id":3297,"date":"2026-04-14T11:15:20","date_gmt":"2026-04-14T09:15:20","guid":{"rendered":"https:\/\/jakobssonlab.iob.uu.se\/?p=3297"},"modified":"2026-04-14T11:15:20","modified_gmt":"2026-04-14T09:15:20","slug":"short-report-from-probgen-2026","status":"publish","type":"post","link":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/2026\/04\/14\/short-report-from-probgen-2026\/","title":{"rendered":"Short report from ProbGen 2026"},"content":{"rendered":"\n
\"\"
Aerial View of the UC Berkeley Campus & Sather Tower<\/figcaption><\/figure>\n\n\n\n

Mark Chernyshev attended the Probabilistic Modelling in Genomics conference in Berkeley, California, 25-28 March 2026 (ProbGen2026<\/a>). The conference attracted around 1000 participants, and approximately 300 posters were displayed and discussed.<\/p>\n\n\n\n

Mark presented some of his research in the poster: Detecting Sapiens-Specific Selective Sweeps by Leveraging Deep Divergence and Machine Learning<\/em>.<\/p>\n\n\n\n

Abstract<\/h4>\n\n\n\n

Identifying the selective pressures specific to the Homo sapiens lineage is difficult because sweep signals erode over relevant time scales.\u00a0Previous methods used archaic genomes to detect extended lineage sorting (Peyr\u00e9gne et al. 2017) or haplotype inconsistency between modern humans and archaics (Racimo et al. 2016), but neither directly targets the sapiens-specific branch.\u00a0Here we leverage the deepest divergence within modern humans, using ancient southern Africans as unadmixed representatives of the\u00a0 Khoe-San population branch (Jakobsson et al. 2026), whose ancestors diverged from all other modern humans ~300kya, to define a branch-length statistic that specifically targets sapiens evolution, incorporating all five published high-coverage archaic genomes. We couple this statistic with a machine learning approach trained using evolutionary simulators, enabling detection of candidate sweep regions.<\/p>\n\n\n\n

\n
ProbGen2026 abstract booklet<\/a><\/div>\n<\/div>\n\n\n\n
\"\"
Mark reports his impressions and news from the ProbGen2026 at the Jakobsson Lab weekly meeting.<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"

Mark Chernyshev attended the Probabilistic Modelling in Genomics conference in Berkeley, California, 25-28 March 2026 (ProbGen2026). The conference attracted around […]<\/p>\n","protected":false},"author":2,"featured_media":3299,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20,158],"tags":[240,46,239],"class_list":["post-3297","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-events","category-people","tag-conference","tag-genomics","tag-probgen2026"],"_links":{"self":[{"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/posts\/3297","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/comments?post=3297"}],"version-history":[{"count":1,"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/posts\/3297\/revisions"}],"predecessor-version":[{"id":3300,"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/posts\/3297\/revisions\/3300"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/media\/3299"}],"wp:attachment":[{"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/media?parent=3297"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/categories?post=3297"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jakobssonlab.iob.uu.se\/index.php\/wp-json\/wp\/v2\/tags?post=3297"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}